PRIMARY SJÖGREN SYNDROME AND PERIODONTAL INFECTION: ASSOCIATION AND EVIDENCE
Name: PAULA SILVA BRAGA
Publication date: 07/02/2024
Examining board:
Name |
Role |
|---|---|
| CARLOS GRAEFF TEIXEIRA | Examinador Interno |
| EDSON THEODORO DOS SANTOS NETO | Examinador Externo |
| FERNANDA CAMPOS ROSETTI LESSA | Examinador Externo |
| PAULA DOS PASSOS MENEZES | Examinador Externo |
Summary: BRAGA, P.S. Primary Sjögren's Syndrome and Periodontal Infection: association and evidence. Doctoral Thesis – Postgraduate Program in Infectious diseases, Federal University of Espírito Santo, 2023.
Introduction: Patients with Primary Sjögren's Syndrome (PSS) often experience reduced salivary flow and increased oral infections. Although studies have investigated the potential relationship between periodontal diseases (PD) and PSS, due to their significance in health decision-making, a solid connection between the two has not yet been established. Objective: To systematically and analytically identify the outcomes and available evidence on the clinicopathological manifestations of PD in individuals with PSS. Methods: A search was conducted in the databases Embase, Pubmed/Medline, Web of Science, Scopus, and Lilacs, as well as grey literature sources Google Scholar, Livivo, Opengrey, and Proquest Dissertations & Thesis Global to identify studies that assessed the effects of PD in PSS. Case-control studies, published without restriction on year and language, were sought by two independent reviewers (Prospero ID NUMBER: CRD42021256485). The methodological quality assessment was critically evaluated using the Newcastle-Ottawa Scale (NOS) tool. Random-effects models were used for quantitative analyses. Results: A total of twelve studies were included. Meta-analysis did not reveal any substantial effect of PD on PSS in the NIC, IP, IG, and SS indices of PD patients when compared to controls, but a high degree of study heterogeneity was found (I2 > 89%). Higher DMFT (95% CI: 4.94 [0.71 to 9.16]) and lower stimulated salivary flow (95% CI: -1.58 [-1.93 to -1.23]) were observed in PSS. Additionally, sensitivity analysis showed a worse gingival index (95% CI: 2.94 [0.10 to 5.78]) in PSS patients compared to the control group. Conclusion: Although the analyzed studies that assessed the relationship between PD and PSS presented some periodontal peculiarities, such as a worse inflammatory gingival condition, the quality of evidence is low. Therefore, the information available in this study should be interpreted with caution. The results emphasize the need for additional studies for a more definitive understanding of the relationship between PSS and periodontal conditions.
