Name: GLÊNIA DAROS SARNÁGLIA
Publication date: 31/03/2020
Advisor:
Name |
Role |
|---|---|
| DANIEL CLAUDIO DE OLIVEIRA GOMES | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| BLIMA FUX | Internal Examiner * |
| DANIEL CLAUDIO DE OLIVEIRA GOMES | Advisor * |
| KÊNIA VALÉRIA DOS SANTOS | Internal Examiner * |
| MARCO CESAR CUNEGUNDES GUIMARÃES | External Examiner * |
Summary: It has long been accepted that immunity or susceptibility to disease depends on the measure of nutrition. Nutritional imbalances affect the ability to host the protective inflammatory response, causing damage to immune defenses. Many of these mechanisms remain mobile to be elucidated. Using a model of mice fed an obesity-inducing diet, rich in simple carbohydrates and saturated fat, the influence of eating behavior on the development of visceral leishmaniasis used by L. infantum was examined. Female mice C57BL / 6, foods with diet control (CTRL) or with a high sugar and fat diet (HSB) were infected with 107L. infantum promastigotes after obesity treatment and sacrificed in parasitism peak. The administration of a diet rich in simple carbohydrates and saturated fat was efficient in inducing experimental obesity in a murine model, causing systemic changes. Obese mice were able to generate a high inflammatory response in response to an infection with L. infantum but increased susceptibility to infection. In view of these findings, we carried out a broad characterization of the expression of inhibitory receptors in T cell compartments during obesity and infection, and we were unable to associate the increased susceptibility in obese animals to these factors. These data suggest that a macroenvironmental hypercaloric can directly interfere in the response to signals from pathogenic organisms and distort the development of an anti-leishmania immunity. Still related to nutrition and infections, available on the influence of an amino acid-based diet in the same context. C57BL / 6 mice fed a control diet (CTRL) or a diet with amino acids as a source of protein (AA) were infected with 107 L. infantum promastigotes after weaning. Mice that received an AA diet showed increased susceptibility to infection, with changes in the inflammatory profile, decreased T cells, macrophages and cell proliferation. These data together show that diet is an important factor that influences the function and development of the immune system in the face of infections.
