Expression of Inhibitory Receptors in T Cells During Infection By Leishmania Braziliensis
Name: JULIANA ARAUJO SILVA
Publication date: 12/09/2018
Advisor:
Name |
Role |
|---|---|
| DANIEL CLAUDIO DE OLIVEIRA GOMES | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| DANIEL CLAUDIO DE OLIVEIRA GOMES | Advisor * |
Summary: Leishmaniasis is a term used generically to define a complex of clinically different
diseases caused by protozoa of the genus Leishmania. Leishmaniasis is classified as
Visceral Leishmaniasis (VL) and American Tegumentary Leishmaniasis (ATL), the
latter includes cutaneous and mucocutaneous clinical manifestations. Infectious
processes that result in antigenic persistence or chronic inflammatory syndromes affect
the effector functions of antigen-specific T cells, being characterized by high expression
of inhibitory receptors such as: PD-1, TIM-3, CTLA-4, KLRG-1 and CD57. In this
work we aimed to evaluate the expression of PD-1, CTLA-4, KLRG-1, CD57 and TIM3 receptors in CD4 + and CD8 + T cells. We have shown higher frequencies of PD-1,
CTLA-4, CD57, KLRG-1 and TIM-3 in patients with cutaneous leishmaniasis.
Simultaneously an increase in the production of IFN-γ, TNF-α and CRP was observed,
which directly reflects the microbicidal capacity and inflammation profile in the
patients. Our results amplify the knowledge of the characterization of the immune
response during leishmaniasis, which can be further explored to aid in the development
of new therapeutic strategies.
