Predictors of mortality in children under 15 years old Who acquired HIV from mother to child transmission in Paraguay
Name: GLORIA CELESTE AGUILAR BARRETO
Publication date: 30/11/2017
Advisor:
Name |
Role |
|---|---|
| ANGELICA ESPINOSA BARBOSA MIRANDA | Advisor * |
Examining board:
| Name |
Role |
|---|---|
| ANGELICA ESPINOSA BARBOSA MIRANDA | Advisor * |
| CRISPIM CERUTTI JUNIOR | Internal Examiner * |
| SANDRA FAGUNDES MOREIRA DA SILVA | External Examiner * |
Summary: Introduction: Efforts have been made in Paraguay to improve the response to HIV infection. In the context of the Sustainable Development Goals, it is important to evaluate the impact of interventions in pediatrics.
Objective: To estimate the mortality rate and predictors in children who acquired HIV through mother-to-child transmission between January 2000 and December 2014.
Material and methods: An observational, cohort-type study was performed with follow-up from the birth of children and adolescents who were <15 years of age at the time of recruitment. Data were obtained from clinical records. Death data were recorded from medical records and confirmations of deaths from death certificates. Survival analysis techniques were used to estimate the incidence of death
Results: A total of 302 subjects were included, 216 (71.6%)% under six years of age,148 ( 51.0%) male, and 214( 70.9%)% of the main metropolitan area. There were 52 deaths (17.2%) with an overall mortality rate of 2.06 deaths / 100 person-years. Children with hemoglobin ≤9 g/dL were 2 times more likely to die compared to hemoglobin > 9 g / dL [ (hazard ratio; 2.27, (95% CI: 1.01, 5.10) ]. The risk of death was 74% lower for children diagnosed in the period ≥ 2010 compared to those diagnosed before 2010 [hazard ratio ; 0.26, (95 CI%, 0.07-0-88)] . Conclusion: The mortality of children with HIV in Paraguay is high, and anemia is associated with mortality. Improving prenatal care and pediatric follow-up in an effort to early diagnose children infected by mother-to-child transmission should be an integral part of the health care offered to the child with HIV infection.
